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Targeting Protein Prenylation in Progeria
A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of thi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725554/ https://ncbi.nlm.nih.gov/pubmed/23390246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005229 |
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