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Targeting Protein Prenylation in Progeria

A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of thi...

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Bibliografiske detaljer
Main Authors: Young, Stephen G., Yang, Shao H., Davies, Brandon S. J., Jung, Hea-Jin, Fong, Loren G.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725554/
https://ncbi.nlm.nih.gov/pubmed/23390246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005229
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