Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

Zmpste24 is a metalloproteinase required for the processing of prelamin A to lamin A, a structural component of the nuclear lamina. Zmpste24 deficiency results in the accumulation of prelamin A within cells, a complete loss of mature lamin A, and misshapen nuclear envelopes. Zmpste24-deficient (Zmps...

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Detalhes bibliográficos
Main Authors: Fong, Loren G., Ng, Jennifer K., Meta, Margarita, Coté, Nathan, Yang, Shao H., Stewart, Colin L., Sullivan, Terry, Burghardt, Andrew, Majumdar, Sharmila, Reue, Karen, Bergo, Martin O., Young, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC536056/
https://ncbi.nlm.nih.gov/pubmed/15608054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408558102
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