Increasing the length of progerin’s isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor. The farnesyl lipid anchor helps to target progerin to membrane surfaces at the nuclear rim, where it disrupts the integ...

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Hauptverfasser: Davies, Brandon S. J., Yang, Shao H., Farber, Emily, Lee, Roger, Buck, Suzanne B., Andres, Douglas A., Spielmann, H. Peter, Agnew, Brian J., Tamanoi, Fuyuhiko, Fong, Loren G., Young, Stephen G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837462/
https://ncbi.nlm.nih.gov/pubmed/18757838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800424-JLR200
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