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Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

To better understand the factors that influence the activity and specificity of antisense oligonucleotides (ASOs), we designed a minigene encoding superoxide dismutase 1 (SOD-1) and cloned the minigene into vectors for T7 transcription of pre-mRNA and splicing in a nuclear extract or for stable inte...

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Autors principals: Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114480/
https://ncbi.nlm.nih.gov/pubmed/25072142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101752
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