Highly efficient endonucleolytic cleavage of RNA by a Cys(2)His(2) zinc-finger peptide

Por Lima, Walt F., Crooke, Stanley T.
Publicado em 1999

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

Por Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Publicado em 2007

Human RNase H1 Is Associated with Protein P32 and Is Involved in Mitochondrial Pre-rRNA Processing

Por Wu, Hongjiang, Sun, Hong, Liang, Xuehai, Lima, Walt F., Crooke, Stanley T.
Publicado em 2013

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

Por Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Publicado em 2014

RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

Por Lima, Walt F., De Hoyos, Cheryl L., Liang, Xue-hai, Crooke, Stanley T.
Publicado no Nucleic Acids Res (2016)

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

Por Vickers, Timothy A., Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Linsley, Peter S., Crooke, Stanley T.
Publicado em 2009

Binding and Cleavage Specificities of Human Argonaute2

Por Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Sun, Hong, Murray, Heather M., Crooke, Stanley T.
Publicado em 2009

Structural analysis of human Argonaute-2 bound to a modified siR-NA guide

Por Schirle, Nicole T., Kinberger, Garth A., Murray, Heather F., Lima, Walt F., Prakash, Thazha P., MacRae, Ian J.
Publicado no J Am Chem Soc (2016)

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

Por Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Pendergraff, Hannah, Swayze, Eric E., Lima, Walt F., Hu, Jiaxin, Prakash, Thazha P., Corey, David R.
Publicado em 2013

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

Por Lima, Walt F., Murray, Heather M., Damle, Sagar S., Hart, Christopher E., Hung, Gene, De Hoyos, Cheryl Li, Liang, Xue-Hai, Crooke, Stanley T.
Publicado no Nucleic Acids Res (2016)

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Por Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.
Publicado em 2012

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

Por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado no Nucleic Acids Res (2015)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado no Nucleic Acids Res (2014)

Exploring the Effect of Sequence Length and Composition on Allele-Selective Inhibition of Human Huntingtin Expression by Single-Stranded Silencing RNAs

Por Hu, Jiaxin, Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Lee, Suheung, Pendergraff, Hannah, Boubaker, Jihane, Artates, Jonathan W., Lagier-Tourenne, Clotilde, Lima, Walt F., Swayze, Eric E., Prakash, Thazha P., Corey, David R.
Publicado em 2014

Allele-Selective Inhibition of Mutant Atrophin-1 Expression by Duplex and Single-Stranded RNAs

Por Hu, Jiaxin, Liu, Jing, Narayanannair, K. Jayaprakash, Lackey, Jeremy G., Kuchimanchi, Satya, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Swayze, Eric E., Lima, Walt F., Prakash, Thazha P., Xiang, Qin, Martinez, Carlos, Corey, David R.
Publicado em 2014

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Por Prakash, Thazha P., Graham, Mark J., Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F., Riney, Stan, Booten, Sheri L., Murray, Susan F., Gaus, Hans, Crosby, Jeff, Lima, Walt F., Guo, Shuling, Monia, Brett P., Swayze, Eric E., Seth, Punit P.
Publicado em 2014