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Allele-Selective Inhibition of Mutant Atrophin-1 Expression by Duplex and Single-Stranded RNAs
[Image: see text] Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive neurodegenerative disorder that currently has no curative treatments. DRPLA is caused by an expansion of a CAG trinucleotide repeat region within the protein-encoding sequence of the atrophin-1 (ATN-1) gene. Inhibition o...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108179/ https://ncbi.nlm.nih.gov/pubmed/24981774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500610r |
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