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Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function
Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no RNase H1 activity in hepatocytes showed increased R-loop levels and reduced mitochondrial encoded DNA and mRNA levels, suggesting impaired mitochondrial R-loop processing, transcription and mitochondr...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914116/ https://ncbi.nlm.nih.gov/pubmed/27131367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw350 |
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