Rethinking ALS: the FUS about TDP-43

Por Lagier-Tourenne, Clotilde, Cleveland, Don W.
Publicado em 2009

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Por Lagier-Tourenne, Clotilde, Polymenidou, Magdalini, Cleveland, Don W.
Publicado em 2010

RNA binding proteins in neurodegeneration: Seq and you shall receive

Por Nussbacher, Julia K., Batra, Ranjan, Lagier-Tourenne, Clotilde, Yeo, Gene W.
Publicado no Trends Neurosci (2015)

Misregulated RNA processing in amyotrophic lateral sclerosis

Por Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Hutt, Kasey R., Bennett, C. Frank, Cleveland, Don W., Yeo, Gene W.
Publicado em 2012

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

Por Ling, Shuo-Chien, Albuquerque, Claudio P., Han, Joo Seok, Lagier-Tourenne, Clotilde, Tokunaga, Seiya, Zhou, Huilin, Cleveland, Don W.
Publicado em 2010

Homozygous Mutation in SPATA16 Is Associated with Male Infertility in Human Globozoospermia

Por Dam, Anika H. D. M. , Koscinski, Isabelle , Kremer, Jan A. M. , Moutou, Céline , Jaeger, Anne-Sophie , Oudakker, Astrid R. , Tournaye, Herman , Charlet, Nicolas , Lagier-Tourenne, Clotilde , van Bokhoven, Hans , Viville, Stéphane 
Publicado em 2007

Exploring the Effect of Sequence Length and Composition on Allele-Selective Inhibition of Human Huntingtin Expression by Single-Stranded Silencing RNAs

Por Hu, Jiaxin, Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Lee, Suheung, Pendergraff, Hannah, Boubaker, Jihane, Artates, Jonathan W., Lagier-Tourenne, Clotilde, Lima, Walt F., Swayze, Eric E., Prakash, Thazha P., Corey, David R.
Publicado em 2014

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Por Sun, Shuying, Sun, Ying, Ling, Shuo-Chien, Ferraiuolo, Laura, McAlonis-Downes, Melissa, Zou, Yiyang, Drenner, Kevin, Wang, Yin, Ditsworth, Dara, Tokunaga, Seiya, Kopelevich, Alex, Kaspar, Brian K., Lagier-Tourenne, Clotilde, Cleveland, Don W.
Publicado no Proc Natl Acad Sci U S A (2015)

Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ(10) deficiency

Por Quinzii, Catarina M., López, Luis C., Gilkerson, Robert W., Dorado, Beatriz, Coku, Jorida, Naini, Ali B., Lagier-Tourenne, Clotilde, Schuelke, Markus, Salviati, Leonardo, Carrozzo, Rosalba, Santorelli, Filippo, Rahman, Shamima, Tazir, Meriem, Koenig, Michel, DiMauro, Salvatore, Hirano, Michio
Publicado em 2010

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

Por Meyer, Kathrin, Ferraiuolo, Laura, Miranda, Carlos J., Likhite, Shibi, McElroy, Sohyun, Renusch, Samantha, Ditsworth, Dara, Lagier-Tourenne, Clotilde, Smith, Richard A., Ravits, John, Burghes, Arthur H., Shaw, Pamela J., Cleveland, Don W., Kolb, Stephen J., Kaspar, Brian K.
Publicado em 2014

ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP

Por Sun, Shuying, Ling, Shuo-Chien, Qiu, Jinsong, Albuquerque, Claudio P., Zhou, Yu, Tokunaga, Seiya, Li, Hairi, Qiu, Haiyan, Bui, Anh, Yeo, Gene W., Huang, Eric J., Eggan, Kevin, Zhou, Huilin, Fu, Xiang-Dong, Lagier-Tourenne, Clotilde, Cleveland, Don W.
Publicado no Nat Commun (2015)

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

Por Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Hutt, Kasey R., Huelga, Stephanie C., Moran, Jacqueline, Liang, Tiffany Y., Ling, Shuo-Chien, Sun, Eveline, Wancewicz, Edward, Mazur, Curt, Kordasiewicz, Holly, Sedaghat, Yalda, Donohue, John Paul, Shiue, Lily, Bennett, C. Frank, Yeo, Gene W., Cleveland, Don W.
Publicado em 2011

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Por Arnold, Eveline S., Ling, Shuo-Chien, Huelga, Stephanie C., Lagier-Tourenne, Clotilde, Polymenidou, Magdalini, Ditsworth, Dara, Kordasiewicz, Holly B., McAlonis-Downes, Melissa, Platoshyn, Oleksandr, Parone, Philippe A., Da Cruz, Sandrine, Clutario, Kevin M., Swing, Debbie, Tessarollo, Lino, Marsala, Martin, Shaw, Christopher E., Yeo, Gene W., Cleveland, Don W.
Publicado em 2013

ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q(10) Deficiency

Por Lagier-Tourenne, Clotilde, Tazir, Meriem, López, Luis Carlos, Quinzii, Catarina M., Assoum, Mirna, Drouot, Nathalie, Busso, Cleverson, Makri, Samira, Ali-Pacha, Lamia, Benhassine, Traki, Anheim, Mathieu, Lynch, David R., Thibault, Christelle, Plewniak, Frédéric, Bianchetti, Laurent, Tranchant, Christine, Poch, Olivier, DiMauro, Salvatore, Mandel, Jean-Louis, Barros, Mario H., Hirano, Michio, Koenig, Michel
Publicado em 2008

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Por Lagier-Tourenne, Clotilde, Polymenidou, Magdalini, Hutt, Kasey R, Vu, Anthony Q, Baughn, Michael, Huelga, Stephanie C, Clutario, Kevin M, Ling, Shuo-Chien, Liang, Tiffany Y, Mazur, Curt, Wancewicz, Edward, Kim, Aneeza S, Watt, Andy, Freier, Sue, Hicks, Geoffrey G, Donohue, John Paul, Shiue, Lily, Bennett, C Frank, Ravits, John, Cleveland, Don W, Yeo, Gene W
Publicado em 2012

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

Por Scekic‐Zahirovic, Jelena, Sendscheid, Oliver, El Oussini, Hajer, Jambeau, Mélanie, Sun, Ying, Mersmann, Sina, Wagner, Marina, Dieterlé, Stéphane, Sinniger, Jérome, Dirrig‐Grosch, Sylvie, Drenner, Kevin, Birling, Marie‐Christine, Qiu, Jinsong, Zhou, Yu, Li, Hairi, Fu, Xiang‐Dong, Rouaux, Caroline, Shelkovnikova, Tatyana, Witting, Anke, Ludolph, Albert C, Kiefer, Friedemann, Storkebaum, Erik, Lagier‐Tourenne, Clotilde, Dupuis, Luc
Publicado no EMBO J (2016)

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72

Por van Blitterswijk, Marka, Gendron, Tania F., Baker, Matthew C., DeJesus-Hernandez, Mariely, Finch, NiCole A., Brown, Patricia H., Daughrity, Lillian M., Murray, Melissa E., Heckman, Michael G., Jiang, Jie, Lagier-Tourenne, Clotilde, Edbauer, Dieter, Cleveland, Don W., Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Petrucelli, Leonard, Boeve, Bradley F., Graff-Radford, Neill R., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa
Publicado no Acta Neuropathol (2015)

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

Por Lagier-Tourenne, Clotilde, Baughn, Michael, Rigo, Frank, Sun, Shuying, Liu, Patrick, Li, Hai-Ri, Jiang, Jie, Watt, Andrew T., Chun, Seung, Katz, Melanie, Qiu, Jinsong, Sun, Ying, Ling, Shuo-Chien, Zhu, Qiang, Polymenidou, Magdalini, Drenner, Kevin, Artates, Jonathan W., McAlonis-Downes, Melissa, Markmiller, Sebastian, Hutt, Kasey R., Pizzo, Donald P., Cady, Janet, Harms, Matthew B., Baloh, Robert H., Vandenberg, Scott R., Yeo, Gene W., Fu, Xiang-Dong, Bennett, C. Frank, Cleveland, Don W., Ravits, John
Publicado em 2013

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

Por Gendron, Tania F., van Blitterswijk, Marka, Bieniek, Kevin F., Daughrity, Lillian M., Jiang, Jie, Rush, Beth K., Pedraza, Otto, Lucas, John A., Murray, Melissa E., Desaro, Pamela, Robertson, Amelia, Overstreet, Karen, Thomas, Colleen S., Crook, Julia E., Castanedes-Casey, Monica, Rousseau, Linda, Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Boeve, Bradley F., Graff-Radford, Neill R., Rademakers, Rosa, Lagier-Tourenne, Clotilde, Edbauer, Dieter, Cleveland, Don W., Dickson, Dennis W., Petrucelli, Leonard, Boylan, Kevin B.
Publicado no Acta Neuropathol (2015)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Por Zhang, Yong-Jie, Gendron, Tania F, Grima, Jonathan C, Sasaguri, Hiroki, Jansen-West, Karen, Xu, Ya-Fei, Katzman, Rebecca B, Gass, Jennifer, Murray, Melissa E, Shinohara, Mitsuru, Lin, Wen-Lang, Garrett, Aliesha, Stankowski, Jeannette N, Daughrity, Lillian, Tong, Jimei, Perkerson, Emilie A, Yue, Mei, Chew, Jeannie, Castanedes-Casey, Monica, Kurti, Aishe, Wang, Zizhao S, Liesinger, Amanda M, Baker, Jeremy D, Jiang, Jie, Lagier-Tourenne, Clotilde, Edbauer, Dieter, Cleveland, Don W, Rademakers, Rosa, Boylan, Kevin B, Bu, Guojun, Link, Christopher D, Dickey, Chad A, Rothstein, Jeffrey D, Dickson, Dennis W, Fryer, John D, Petrucelli, Leonard
Publicado no Nat Neurosci (2016)