Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS binds to RNAs from >5,500 genes in mouse and human brain, primarily through a GUGGU-binding motif. We identified a sa...

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Autori principali: Lagier-Tourenne, Clotilde, Polymenidou, Magdalini, Hutt, Kasey R, Vu, Anthony Q, Baughn, Michael, Huelga, Stephanie C, Clutario, Kevin M, Ling, Shuo-Chien, Liang, Tiffany Y, Mazur, Curt, Wancewicz, Edward, Kim, Aneeza S, Watt, Andy, Freier, Sue, Hicks, Geoffrey G, Donohue, John Paul, Shiue, Lily, Bennett, C Frank, Ravits, John, Cleveland, Don W, Yeo, Gene W
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586380/
https://ncbi.nlm.nih.gov/pubmed/23023293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3230
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