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Understanding the role of TDP-43 and FUS/TLS in ALS and beyond
Dominant mutation in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA processing as central in ALS. TDP-43 has binding sites within a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228892/ https://ncbi.nlm.nih.gov/pubmed/21813273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conb.2011.05.029 |
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