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Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

Dominant mutation in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA processing as central in ALS. TDP-43 has binding sites within a...

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Bibliographic Details
Main Authors: Da Cruz, Sandrine, Cleveland, Don W.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228892/
https://ncbi.nlm.nih.gov/pubmed/21813273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conb.2011.05.029
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