Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Ubiquitous expression of amyotrophic lateral sclerosis (ALS)-causing mutations in superoxide dismutase 1 (SOD1) provokes noncell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes ar...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sun, Shuying, Sun, Ying, Ling, Shuo-Chien, Ferraiuolo, Laura, McAlonis-Downes, Melissa, Zou, Yiyang, Drenner, Kevin, Wang, Yin, Ditsworth, Dara, Tokunaga, Seiya, Kopelevich, Alex, Kaspar, Brian K., Lagier-Tourenne, Clotilde, Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687558/
https://ncbi.nlm.nih.gov/pubmed/26621731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520639112
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