Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ(10) deficiency

Coenzyme Q(10) (CoQ(10)) is essential for electron transport in the mitochondrial respiratory chain and antioxidant defense. The relative importance of respiratory chain defects, ROS production, and apoptosis in the pathogenesis of CoQ(10) deficiency is unknown. We determined previously that severe...

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Autors principals: Quinzii, Catarina M., López, Luis C., Gilkerson, Robert W., Dorado, Beatriz, Coku, Jorida, Naini, Ali B., Lagier-Tourenne, Clotilde, Schuelke, Markus, Salviati, Leonardo, Carrozzo, Rosalba, Santorelli, Filippo, Rahman, Shamima, Tazir, Meriem, Koenig, Michel, DiMauro, Salvatore, Hirano, Michio
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2010
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996902/
https://ncbi.nlm.nih.gov/pubmed/20495179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-152728
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