Aging Is Not Associated with Proteasome Impairment in UPS Reporter Mice

por Cook, Casey, Gass, Jennifer, Dunmore, Judith, Tong, Jimei, Taylor, Julie, Eriksen, Jason, McGowan, Eileen, Lewis, Jada, Johnston, Jennifer, Petrucelli, Leonard
Publicado 2009

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43

por Xu, Ya-Fei, Prudencio, Mercedes, Hubbard, Jaime M., Tong, Jimei, Whitelaw, Ena C., Jansen-West, Karen, Stetler, Caroline, Cao, Xiangkun, Song, John, Zhang, Yong-Jie
Publicado 2013

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

por Carlomagno, Yari, Chung, Dah-eun Chloe, Yue, Mei, Castanedes-Casey, Monica, Madden, Benjamin J., Dunmore, Judy, Tong, Jimei, DeTure, Michael, Dickson, Dennis W., Petrucelli, Leonard, Cook, Casey
Publicado en J Biol Chem (2017)

The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo

por Sasaguri, Hiroki, Chew, Jeannie, Xu, Ya-Fei, Gendron, Tania F., Garrett, Aliesha, Lee, Chris W., Jansen-West, Karen, Bauer, Peter O., Perkerson, Emilie A., Tong, Jimei, Stetler, Caroline, Zhang, Yong-Jie
Publicado en Brain Res (2016)

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

por Cook, Casey, Dunmore, Judy H., Murray, Melissa E., Scheffel, Kristyn, Shukoor, Nawsheen, Tong, Jimei, Castanedes-Casey, Monica, Phillips, Virginia, Rousseau, Linda, Penuliar, Michael S., Kurti, Aishe, Dickson, Dennis W., Petrucelli, Leonard, Fryer, John D.
Publicado 2013

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

por Zhang, Yong-Jie, Xu, Ya-Fei, Cook, Casey, Gendron, Tania F., Roettges, Paul, Link, Christopher D., Lin, Wen-Lang, Tong, Jimei, Castanedes-Casey, Monica, Ash, Peter, Gass, Jennifer, Rangachari, Vijayaraghavan, Buratti, Emanuele, Baralle, Francisco, Golde, Todd E., Dickson, Dennis W., Petrucelli, Leonard
Publicado 2009

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

por Xu, Ya-Fei, Gendron, Tania F., Zhang, Yong-Jie, Lin, Wen-Lang, D'Alton, Simon, Sheng, Hong, Casey, Monica Castanedes, Tong, Jimei, Knight, Joshua, Yu, Xin, Rademakers, Rosa, Boylan, Kevin, Hutton, Mike, McGowan, Eileen, Dickson, Dennis W., Lewis, Jada, Petrucelli, Leonard
Publicado 2010

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

por Carlomagno, Yari, Chung, Dah-eun Chloe, Yue, Mei, Kurti, Aishe, Avendano, Nicole M., Castanedes-Casey, Monica, Hinkle, Kelly M., Jansen-West, Karen, Daughrity, Lillian M., Tong, Jimei, Phillips, Virginia, Rademakers, Rosa, DeTure, Michael, Fryer, John D., Dickson, Dennis W., Petrucelli, Leonard, Cook, Casey
Publicado en Acta Neuropathol Commun (2019)

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

por Cook, Casey N., Wu, Yanwei, Odeh, Hana M., Gendron, Tania F., Jansen-West, Karen, del Rosso, Giulia, Yue, Mei, Jiang, Peizhou, Gomes, Edward, Tong, Jimei, Daughrity, Lillian M., Avendano, Nicole M., Castanedes-Casey, Monica, Shao, Wei, Oskarsson, Björn, Tomassy, Giulio S., McCampbell, Alexander, Rigo, Frank, Dickson, Dennis W., Shorter, James, Zhang, Yong-Jie, Petrucelli, Leonard
Publicado en Sci Transl Med (2020)

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

por Zhang, Yong-Jie, Gendron, Tania F., Ebbert, Mark T. W., O′Raw, Aliesha D., Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N., Daughrity, Lillian M., Tong, Jimei, Song, Yuping, Pickles, Sarah R., Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W., Hu, Wenqian, Gitler, Aaron D., Fryer, John D., Petrucelli, Leonard
Publicado en Nat Med (2018)

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo

por Todd, Tiffany W., McEachin, Zachary T., Chew, Jeannie, Burch, Alexander R., Jansen-West, Karen, Tong, Jimei, Yue, Mei, Song, Yuping, Castanedes-Casey, Monica, Kurti, Aishe, Dunmore, Judith H., Fryer, John D., Zhang, Yong-Jie, Millan, Beatriz San, Bautista, Susana Teijeira, Arias, Manuel, Dickson, Dennis, Gendron, Tania F., Sobrido, María-Jesús, Disney, Matthew D., Bassell, Gary J., Rossoll, Wilfried, Petrucelli, Leonard
Publicado en Cell Rep (2020)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

por Zhang, Yong-Jie, Gendron, Tania F, Grima, Jonathan C, Sasaguri, Hiroki, Jansen-West, Karen, Xu, Ya-Fei, Katzman, Rebecca B, Gass, Jennifer, Murray, Melissa E, Shinohara, Mitsuru, Lin, Wen-Lang, Garrett, Aliesha, Stankowski, Jeannette N, Daughrity, Lillian, Tong, Jimei, Perkerson, Emilie A, Yue, Mei, Chew, Jeannie, Castanedes-Casey, Monica, Kurti, Aishe, Wang, Zizhao S, Liesinger, Amanda M, Baker, Jeremy D, Jiang, Jie, Lagier-Tourenne, Clotilde, Edbauer, Dieter, Cleveland, Don W, Rademakers, Rosa, Boylan, Kevin B, Bu, Guojun, Link, Christopher D, Dickey, Chad A, Rothstein, Jeffrey D, Dickson, Dennis W, Fryer, John D, Petrucelli, Leonard
Publicado en Nat Neurosci (2016)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

por Zhang, Yong-Jie, Guo, Lin, Gonzales, Patrick K., Gendron, Tania F., Wu, Yanwei, Jansen-West, Karen, O’Raw, Aliesha D., Pickles, Sarah R., Prudencio, Mercedes, Carlomagno, Yari, Gachechiladze, Mariam A., Ludwig, Connor, Tian, Ruilin, Chew, Jeannie, DeTure, Michael, Lin, Wen-Lang, Tong, Jimei, Daughrity, Lillian M., Yue, Mei, Song, Yuping, Andersen, Jonathan W., Castanedes-Casey, Monica, Kurti, Aishe, Datta, Abhishek, Antognetti, Giovanna, McCampbell, Alexander, Rademakers, Rosa, Oskarsson, Björn, Dickson, Dennis W., Kampmann, Martin, Ward, Michael E., Fryer, John D., Link, Christopher D., Shorter, James, Petrucelli, Leonard
Publicado en Science (2019)

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

por Gendron, Tania F., Chew, Jeannie, Stankowski, Jeannette N., Hayes, Lindsey R., Zhang, Yong-Jie, Prudencio, Mercedes, Carlomagno, Yari, Daughrity, Lillian M., Jansen-West, Karen, Perkerson, Emilie A., O’Raw, Aliesha, Cook, Casey, Pregent, Luc, Belzil, Veronique, van Blitterswijk, Marka, Tabassian, Lilia J., Lee, Chris W., Yue, Mei, Tong, Jimei, Song, Yuping, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Dickson, Dennis W., Rademakers, Rosa, Fryer, John D., Rush, Beth K., Pedraza, Otto, Caputo, Ana M., Desaro, Pamela, Palmucci, Carla, Robertson, Amelia, Heckman, Michael G., Diehl, Nancy N., Wiggs, Edythe, Tierney, Michael, Braun, Laura, Farren, Jennifer, Lacomis, David, Ladha, Shafeeq, Fournier, Christina N., McCluskey, Leo F., Elman, Lauren B., Toledo, Jon B., McBride, Jennifer D., Tiloca, Cinzia, Morelli, Claudia, Poletti, Barbara, Solca, Federica, Prelle, Alessandro, Wuu, Joanne, Jockel-Balsarotti1, Jennifer, Rigo, Frank, Ambrose, Christine, Datta, Abhishek, Yang, Weixing, Raitcheva, Denitza, Antognetti, Giovanna, McCampbell, Alexander, Van Swieten, John C., Miller, Bruce L., Boxer, Adam L., Brown, Robert H., Bowser, Robert, Miller, Timothy M., Trojanowski, John Q., Grossman, Murray, Berry, James D., Hu, William T., Ratti, Antonia, Traynor, Bryan J., Disney, Matthew D., Benatar, Michael, Silani, Vincenzo, Glass, Jonathan D., Floeter, Mary Kay, Rothstein, Jeffrey D., Boylan, Kevin B., Petrucelli, Leonard
Publicado en Sci Transl Med (2017)