The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo

Inclusions of Tar DNA- binding protein 43 (TDP-43) are a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP). Pathological TDP-43 exhibits the disease-specific biochemical signatures, which include its ubiquiti...

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Bibliografiska uppgifter
I publikationen:Brain Res
Huvudupphovsmän: Sasaguri, Hiroki, Chew, Jeannie, Xu, Ya-Fei, Gendron, Tania F., Garrett, Aliesha, Lee, Chris W., Jansen-West, Karen, Bauer, Peter O., Perkerson, Emilie A., Tong, Jimei, Stetler, Caroline, Zhang, Yong-Jie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003772/
https://ncbi.nlm.nih.gov/pubmed/27155453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2016.04.069
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