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The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation
TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal dementia—frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP). To date, the C-terminus...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3699067/ https://ncbi.nlm.nih.gov/pubmed/23575225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt166 |
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