Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Inclusions of TAR DNA-binding protein-43 (TDP-43), a nuclear protein that regulates transcription and RNA splicing, are the defining histopathological feature of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-Us) and sporadic and familial forms of amyotrophic lateral scle...

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Hlavní autoři: Zhang, Yong-Jie, Xu, Ya-Fei, Cook, Casey, Gendron, Tania F., Roettges, Paul, Link, Christopher D., Lin, Wen-Lang, Tong, Jimei, Castanedes-Casey, Monica, Ash, Peter, Gass, Jennifer, Rangachari, Vijayaraghavan, Buratti, Emanuele, Baralle, Francisco, Golde, Todd E., Dickson, Dennis W., Petrucelli, Leonard
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671323/
https://ncbi.nlm.nih.gov/pubmed/19383787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900688106
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