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Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
BACKGROUND: A G(4)C(2) hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). Putative disease mechanisms underlying c9FTD/ALS include toxicity from sense G(4)C(2) and antisense G(2)C(4)...
Guardat en:
| Publicat a: | Mol Neurodegener |
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| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377782/ https://ncbi.nlm.nih.gov/pubmed/30767771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0310-z |
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