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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins

TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Prpar Mihevc, S., Baralle, Marco, Buratti, Emanuele, Rogelj, Boris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/
https://ncbi.nlm.nih.gov/pubmed/27665936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996
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