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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins
TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/ https://ncbi.nlm.nih.gov/pubmed/27665936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996 |
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