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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins

TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Prpar Mihevc, S., Baralle, Marco, Buratti, Emanuele, Rogelj, Boris
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/
https://ncbi.nlm.nih.gov/pubmed/27665936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996
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