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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins

TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Prpar Mihevc, S., Baralle, Marco, Buratti, Emanuele, Rogelj, Boris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/
https://ncbi.nlm.nih.gov/pubmed/27665936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996
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