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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins
TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/ https://ncbi.nlm.nih.gov/pubmed/27665936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996 |
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