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TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins
TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036055/ https://ncbi.nlm.nih.gov/pubmed/27665936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33996 |
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