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The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function
ABSTRACT. Nuclear factor TDP-43 has been shown to play a key role in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, where TDP-43 aggregates accumulate in patient's affected neurons and this event can cause neuronal dysfunction. A major focus of today's research is to discover t...
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| Veröffentlicht in: | Prion |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601194/ https://ncbi.nlm.nih.gov/pubmed/25635624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2015.1011885 |
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