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Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region

TDP-43 is one of the major components of the neuronal and glial inclusions observed in several neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. These characteristic aggregates are a “landmark” of the disease, but their role in the pathogenesis i...

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Hlavní autoři: Budini, Mauricio, Buratti, Emanuele, Stuani, Cristiana, Guarnaccia, Corrado, Romano, Valentina, De Conti, Laura, Baralle, Francisco E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293573/
https://ncbi.nlm.nih.gov/pubmed/22235134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288720
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