Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Transactivation response DNA-binding protein 43 (TDP-43) is a principal component of ubiquitinated inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis (ALS). Mutations in TARDBP, the gene encoding TDP-43, are associated with sporadi...

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Main Authors: Xu, Ya-Fei, Gendron, Tania F., Zhang, Yong-Jie, Lin, Wen-Lang, D'Alton, Simon, Sheng, Hong, Casey, Monica Castanedes, Tong, Jimei, Knight, Joshua, Yu, Xin, Rademakers, Rosa, Boylan, Kevin, Hutton, Mike, McGowan, Eileen, Dickson, Dennis W., Lewis, Jada, Petrucelli, Leonard
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056148/
https://ncbi.nlm.nih.gov/pubmed/20702714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1630-10.2010
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