Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

BACKGROUND: Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral scler...

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Detalhes bibliográficos
Main Authors: Xu, Ya-Fei, Zhang, Yong-Jie, Lin, Wen-Lang, Cao, Xiangkun, Stetler, Caroline, Dickson, Dennis W, Lewis, Jada, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216869/
https://ncbi.nlm.nih.gov/pubmed/22029574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-73
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