Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneratio...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Carlomagno, Yari, Chung, Dah-eun Chloe, Yue, Mei, Kurti, Aishe, Avendano, Nicole M., Castanedes-Casey, Monica, Hinkle, Kelly M., Jansen-West, Karen, Daughrity, Lillian M., Tong, Jimei, Phillips, Virginia, Rademakers, Rosa, DeTure, Michael, Fryer, John D., Dickson, Dennis W., Petrucelli, Leonard, Cook, Casey
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345061/
https://ncbi.nlm.nih.gov/pubmed/30674342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0661-2
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