Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological hallmark of tauopathies, including Alzheimer's disease (AD) and chronic traumatic encephalopathy, but effective therapies directly targeting the tau protein are currently lacking. Herein, we des...

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Detalhes bibliográficos
Main Authors: Cook, Casey, Carlomagno, Yari, Gendron, Tania F., Dunmore, Judy, Scheffel, Kristyn, Stetler, Caroline, Davis, Mary, Dickson, Dennis, Jarpe, Matthew, DeTure, Michael, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857946/
https://ncbi.nlm.nih.gov/pubmed/23962722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt402
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