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Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological hallmark of tauopathies, including Alzheimer's disease (AD) and chronic traumatic encephalopathy, but effective therapies directly targeting the tau protein are currently lacking. Herein, we des...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857946/ https://ncbi.nlm.nih.gov/pubmed/23962722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt402 |
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