The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

Tau accumulation is a major pathological hallmark of Alzheimer’s disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear. Taking advantage of the identification of tau filament cores by cryoelectron microscopy, we demonstrate that the AD tau core possesses the int...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Carlomagno, Yari, Manne, Sireesha, DeTure, Michael, Prudencio, Mercedes, Zhang, Yong-Jie, Al-Shaikh, Rana Hanna, Dunmore, Judith A., Daughrity, Lillian M., Song, Yuping, Castanedes-Casey, Monica, Lewis-Tuffin, Laura J., Nicholson, Katharine A., Wszolek, Zbigniew K., Dickson, Dennis W., Fitzpatrick, Anthony W.P., Petrucelli, Leonard, Cook, Casey N.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094113/
https://ncbi.nlm.nih.gov/pubmed/33730588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108843
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