The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

Tau accumulation is a major pathological hallmark of Alzheimer’s disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear. Taking advantage of the identification of tau filament cores by cryoelectron microscopy, we demonstrate that the AD tau core possesses the int...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Carlomagno, Yari, Manne, Sireesha, DeTure, Michael, Prudencio, Mercedes, Zhang, Yong-Jie, Al-Shaikh, Rana Hanna, Dunmore, Judith A., Daughrity, Lillian M., Song, Yuping, Castanedes-Casey, Monica, Lewis-Tuffin, Laura J., Nicholson, Katharine A., Wszolek, Zbigniew K., Dickson, Dennis W., Fitzpatrick, Anthony W.P., Petrucelli, Leonard, Cook, Casey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094113/
https://ncbi.nlm.nih.gov/pubmed/33730588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108843
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