The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

Tau accumulation is a major pathological hallmark of Alzheimer’s disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear. Taking advantage of the identification of tau filament cores by cryoelectron microscopy, we demonstrate that the AD tau core possesses the int...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Cell Rep
Hoofdauteurs: Carlomagno, Yari, Manne, Sireesha, DeTure, Michael, Prudencio, Mercedes, Zhang, Yong-Jie, Al-Shaikh, Rana Hanna, Dunmore, Judith A., Daughrity, Lillian M., Song, Yuping, Castanedes-Casey, Monica, Lewis-Tuffin, Laura J., Nicholson, Katharine A., Wszolek, Zbigniew K., Dickson, Dennis W., Fitzpatrick, Anthony W.P., Petrucelli, Leonard, Cook, Casey N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094113/
https://ncbi.nlm.nih.gov/pubmed/33730588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108843
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items