Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneratio...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Carlomagno, Yari, Chung, Dah-eun Chloe, Yue, Mei, Kurti, Aishe, Avendano, Nicole M., Castanedes-Casey, Monica, Hinkle, Kelly M., Jansen-West, Karen, Daughrity, Lillian M., Tong, Jimei, Phillips, Virginia, Rademakers, Rosa, DeTure, Michael, Fryer, John D., Dickson, Dennis W., Petrucelli, Leonard, Cook, Casey
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345061/
https://ncbi.nlm.nih.gov/pubmed/30674342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0661-2
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