The role of tau in neurodegeneration

по Gendron, Tania F, Petrucelli, Leonard
Опубликовано 2009

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration

по Gendron, Tania F., Petrucelli, Leonard
Опубликовано 2011

Disease Mechanisms of C9ORF72 Repeat Expansions

по Gendron, Tania F., Petrucelli, Leonard
Опубликовано в: Cold Spring Harb Perspect Med (2018)

Biomarkers for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Associated With Hexanucleotide Expansion Mutations in C9orf72

по Floeter, Mary Kay, Gendron, Tania F.
Опубликовано в: Front Neurol (2018)

TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43

по Gendron, Tania F., Rademakers, Rosa, Petrucelli, Leonard
Опубликовано 2013

Does Obesity-Induced τ Phosphorylation Tip the Scale Toward Dementia?

по Gendron, Tania F., Zhang, Yong-Jie, Petrucelli, Leonard
Опубликовано 2013

RNA-mediated toxicity in neurodegenerative disease

по Belzil, Veronique V., Gendron, Tania F., Petrucelli, Leonard
Опубликовано 2012

Concentration-dependent Effects of Proteasomal Inhibition on tau Processing in a Cellular Model of Tauopathy

по Hamano, Tadanori, Gendron, Tania F., Ko, Li-wen, Yen, Shu-Hui
Опубликовано 2009

Mechanisms of Toxicity in C9FTLD/ALS

по Gendron, Tania F., Belzil, Veronique V., Zhang, Yong-Jie, Petrucelli, Leonard
Опубликовано 2014

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

по Yuva-Aydemir, Yeliz, Almeida, Sandra, Krishnan, Gopinath, Gendron, Tania F., Gao, Fen-Biao
Опубликовано в: Nat Commun (2019)

Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau

по Gendron, Tania F., McCartney, Sharon, Causevic, Ena, Ko, Li-wen, Yen, Shu-Hui
Опубликовано 2008

ARHGEF28 p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion

по Farhan, Sali M.K., Gendron, Tania F., Petrucelli, Leonard, Hegele, Robert A., Strong, Michael J.
Опубликовано в: Neurol Genet (2017)

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

по Cook, Casey, Gendron, Tania F., Scheffel, Kristyn, Carlomagno, Yari, Dunmore, Judy, DeTure, Michael, Petrucelli, Leonard
Опубликовано 2012

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

по Belzil, Veronique V., Bauer, Peter O., Gendron, Tania F., Murray, Melissa E., Dickson, Dennis, Petrucelli, Leonard
Опубликовано 2014

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

по Zhang, Yong-Jie, Gendron, Tania F, Xu, Ya-Fei, Ko, Li-Wen, Yen, Shu-Hui, Petrucelli, Leonard
Опубликовано 2010

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

по Esanov, Rustam, Cabrera, Gabriela Toro, Andrade, Nadja S., Gendron, Tania F., Brown, Robert H., Benatar, Michael, Wahlestedt, Claes, Mueller, Christian, Zeier, Zane
Опубликовано в: Mol Neurodegener (2017)

Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

по Sakae, Nobutaka, Bieniek, Kevin F., Zhang, Yong-Jie, Ross, Kelly, Gendron, Tania F., Murray, Melissa E., Rademakers, Rosa, Petrucelli, Leonard, Dickson, Dennis W.
Опубликовано в: Acta Neuropathol Commun (2018)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

по Cook, Casey, Carlomagno, Yari, Gendron, Tania F., Dunmore, Judy, Scheffel, Kristyn, Stetler, Caroline, Davis, Mary, Dickson, Dennis, Jarpe, Matthew, DeTure, Michael, Petrucelli, Leonard
Опубликовано 2014

Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

по Lopez-Gonzalez, Rodrigo, Lu, Yubing, Gendron, Tania F., Karydas, Anna, Tran, Helene, Yang, Dejun, Petrucelli, Leonard, Miller, Bruce L., Almeida, Sandra, Gao, Fen-Biao
Опубликовано в: Neuron (2016)

Differential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS

по Tran, Helene, Almeida, Sandra, Moore, Jill, Gendron, Tania F., Chalasani, UmaDevi, Lu, Yubing, Du, Xing, Nickerson, Jeffrey A., Petrucelli, Leonard, Weng, Zhiping, Gao, Fen-Biao
Опубликовано в: Neuron (2015)