Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

Frontotemporal lobar degeneration (FTLD) is heterogeneous in clinical presentation, neuropathological characteristics and genetics. An expanded GGGGCC hexanucleotide repeat in C9ORF72 is the most common genetic cause of both FTLD and motor neuron disease (MND). Dipeptide repeat polymers (DPR) are ge...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Sakae, Nobutaka, Bieniek, Kevin F., Zhang, Yong-Jie, Ross, Kelly, Gendron, Tania F., Murray, Melissa E., Rademakers, Rosa, Petrucelli, Leonard, Dickson, Dennis W.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054740/
https://ncbi.nlm.nih.gov/pubmed/30029693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0564-7
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