Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons

Por Boulware, Marissa I., Kordasiewicz, Holly, Mermelstein, Paul G.
Publicado no J Neurosci (2007)

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia

Por Keiser, Megan S., Kordasiewicz, Holly B., McBride, Jodi L.
Publicado no Hum Mol Genet (2016)

Dominant-Negative Suppression of Ca(v)2.1 Currents by α(1)2.1 Truncations Requires the Conserved Interaction Domain for β Subunits

Por Raike, Robert S., Kordasiewicz, Holly B., Thompson, Randall M., Gomez, Christopher M.
Publicado em 2006

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

Por Luo, Xin, Fitzsimmons, Bethany, Mohan, Apoorva, Zhang, Linlin, Terrando, Niccolo, Kordasiewicz, Holly, Ji, Ru-Rong
Publicado no Brain Behav Immun (2017)

2342 Protein production as an early pharmacodynamics biomarker for RNA-targeting therapies

Por Self, Wade K., Schoch, Kathleen, Bollinger, James, Cole, Tracy, Kordasiewicz, Holly, Bateman, Randall, Miller, Timothy
Publicado no J Clin Transl Sci (2018)

Evaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse Models

Por Moore, Lauren R., Rajpal, Gautam, Dillingham, Ian T., Qutob, Maya, Blumenstein, Kate G., Gattis, Danielle, Hung, Gene, Kordasiewicz, Holly B., Paulson, Henry L., McLoughlin, Hayley S.
Publicado no Mol Ther Nucleic Acids (2017)

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Por Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.
Publicado em 2012

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides

Por Reidenbach, Andrew G., Minikel, Eric Vallabh, Zhao, Hien T., Guzman, Stacy G., Leed, Alison J., Mesleh, Michael F., Kordasiewicz, Holly B., Schreiber, Stuart L., Vallabh, Sonia M.
Publicado no Biomolecules (2019)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

Por Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.
Publicado no Mol Ther Nucleic Acids (2017)

Oligonucleotide therapy mitigates disease in Spinocerebellar Ataxia Type 3 mice

Por McLoughlin, Hayley S., Moore, Lauren R., Chopra, Ravi, Komlo, Robert, McKenzie, Megan, Blumenstein, Kate G., Zhao, Hien, Kordasiewicz, Holly B., Shakkottai, Vikram G., Paulson, Henry L.
Publicado no Ann Neurol (2018)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

Por Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.
Publicado no Mol Ther Nucleic Acids (2021)

Protein production is an early biomarker for RNA‐targeted therapies

Por Self, Wade K., Schoch, Kathleen M., Alex, Jacob, Barthélemy, Nicolas, Bollinger, James G., Sato, Chihiro, Cole, Tracy, Kordasiewicz, Holly B., Swayze, Eric, Bateman, Randall J., Miller, Timothy M.
Publicado no Ann Clin Transl Neurol (2018)

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

Por Zhao, Hien Tran, Damle, Sagar, Ikeda-Lee, Karli, Kuntz, Steven, Li, Jian, Mohan, Apoorva, Kim, Aneeza, Hung, Gene, Scheideler, Mark A., Scherer, Steven S., Svaren, John, Swayze, Eric E., Kordasiewicz, Holly B.
Publicado no J Clin Invest (2017)

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

Por Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.
Publicado em 2013

The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration

Por Jafar-nejad, Paymaan, Powers, Berit, Soriano, Armand, Zhao, Hien, Norris, Daniel A, Matson, John, DeBrosse-Serra, Beatrice, Watson, Jamie, Narayanan, Padmakumar, Chun, Seung J, Mazur, Curt, Kordasiewicz, Holly, Swayze, Eric E, Rigo, Frank
Publicado no Nucleic Acids Res (2020)

Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

Por O’Callaghan, Brennon, Hofstra, Bente, Handler, Hillary P., Kordasiewicz, Holly B., Cole, Tracy, Duvick, Lisa, Friedrich, Jillian, Rainwater, Orion, Yang, Praseuth, Benneyworth, Michael, Nichols-Meade, Tessa, Heal, Wesley, Ter Haar, Rachel, Henzler, Christine, Orr, Harry T.
Publicado no Mol Ther Nucleic Acids (2020)

Sustained therapeutic reversal of Huntington’s disease by transient repression of huntingtin synthesis

Por Kordasiewicz, Holly B., Stanek, Lisa M., Wancewicz, Edward V., Mazur, Curt, McAlonis, Melissa M., Pytel, Kimberly A., Artates, Jonathan W., Weiss, Andreas, Cheng, Seng H., Shihabuddin, Lamya S., Hung, Gene, Bennett, C. Frank, Cleveland, Don W.
Publicado em 2012

Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

Por Sullivan, Jenna M., Mazur, Curt, Wolf, Daniel A., Horky, Laura, Currier, Nicolas, Fitzsimmons, Bethany, Hesterman, Jacob, Pauplis, Rachel, Haller, Scott, Powers, Berit, Tayefeh, Leighla, DeBrosse-Serra, Bea, Hoppin, Jack, Kordasiewicz, Holly, Swayze, Eric E., Verma, Ajay
Publicado no J Transl Med (2020)

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.Htt(Q111/+) mouse model of Huntington’s disease

Por Coffey, Sydney R., Bragg, Robert M., Minnig, Shawn, Ament, Seth A., Cantle, Jeffrey P., Glickenhaus, Anne, Shelnut, Daniel, Carrillo, José M., Shuttleworth, Dominic D., Rodier, Julie-Anne, Noguchi, Kimihiro, Bennett, C. Frank, Price, Nathan D., Kordasiewicz, Holly B., Carroll, Jeffrey B.
Publicado no PLoS One (2017)

An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement

Por Poplawski, Shane G., Garbett, Krassimira A., McMahan, Rebekah L., Kordasiewicz, Holly B., Zhao, Hien, Kennedy, Andrew J., Goleva, Slavina B., Sanders, Teresa H., Motley, S. Timothy, Swayze, Eric E., Ecker, David J., Sweatt, J. David, Michael, Todd P., Greer, Celeste B.
Publicado no Mol Ther Nucleic Acids (2020)