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Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

Administration of small interfering RNAs (siRNAs) leads to degradation of specific mRNAs utilizing the cellular RNA interference (RNAi) machinery. It has been demonstrated that co-administration of siRNAs may lead to attenuation of activity of one of the siRNAs. Utilizing antisense and siRNA-mediate...

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Bibliografske podrobnosti
Main Authors: Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
RNA
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095815/
https://ncbi.nlm.nih.gov/pubmed/17905815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm663
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