Competition for RISC binding predicts in vitro potency of siRNA

Short interfering RNAs (siRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC). The use of siRNA in animals is limited partially due to the short half-life of siRNAs in tissues. Chemically modified siRNAs are necessary that maintain mRNA degradation activity, but are more...

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Detalhes bibliográficos
Main Authors: Koller, Erich, Propp, Stephanie, Murray, Heather, Lima, Walter, Bhat, Balkrishen, Prakash, Thaza P., Allerson, Charles R., Swayze, Eric E., Marcusson, Eric G., Dean, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636362/
https://ncbi.nlm.nih.gov/pubmed/16945958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl589
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