Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of the chirality of each of the PS linkages within the 10-base gap. The stereoselectivity was determined to be 98% for each coupling. The objecti...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Chemical Biology and Nucleic Acid Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267618/
https://ncbi.nlm.nih.gov/pubmed/25398895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1115
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