Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modification which enhances stability from nuclease mediated degradation. However, substituting oxygen in the phosphodiester backbone with sulfur introduce chirality into the backbone such that a full PS 16-mer...

詳細記述

保存先:
書誌詳細
出版年:Nucleic Acids Res
主要な著者: Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
Chemical Biology and Nucleic Acid Chemistry
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038945/
https://ncbi.nlm.nih.gov/pubmed/31980820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa031
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