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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6614804/ https://ncbi.nlm.nih.gov/pubmed/31127296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz354 |
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