Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://ncbi.nlm.nih.gov/pubmed/31127296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz354
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