Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://ncbi.nlm.nih.gov/pubmed/31127296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz354
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