Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Chemical Biology and Nucleic Acid Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://ncbi.nlm.nih.gov/pubmed/31127296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz354
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