Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and materials science()

Por Østergaard, Michael E., Hrdlicka, Patrick J.
Publicado em 2011

Functionalized 2′-Amino-α-L-LNA - Directed Positioning of Intercalators for DNA Targeting

Por Kumar, T. Santhosh, Madsen, Andreas S., Østergaard, Michael E., Sau, Sujay P., Wengel, Jesper, Hrdlicka, Patrick J.
Publicado em 2009

C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability

Por Kumar, Pawan, Baral, Bharat, Anderson, Brooke A., Guenther, Dale C., Østergaard, Michael E., Sharma, Pawan K., Hrdlicka, Patrick J.
Publicado em 2014

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Por Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Publicado no Mol Ther Nucleic Acids (2017)

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

Por Sau, Sujay P., Kumar, Pawan, Anderson, Brooke A., Østergaard, Michael E., Deobald, Lee, Paszczynski, Andrzej, Sharma, Pawan K., Hrdlicka, Patrick J.
Publicado em 2009

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA) – A Nuclease Stable Mimic of 2′-Fluoro RNA

Por Seth, Punit P., Yu, Jinghua, Jazayeri, Ali, Pallan, Pradeep S., Allerson, Charles R, Østergaard, Michael E., Liu, Fengwu, Herdewijn, Piet, Egli, Martin, Swayze, Eric E.
Publicado em 2012

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)

Por Kumar, Pawan, Østergaard, Michael E., Baral, Bharat, Anderson, Brooke A., Guenther, Dale C., Kaura, Mamta, Raible, Daniel J., Sharma, Pawan K., Hrdlicka, Patrick J.
Publicado em 2014

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Por Miller, Colton M., Donner, Aaron J., Blank, Emma E., Egger, Andrew W., Kellar, Brianna M., Østergaard, Michael E., Seth, Punit P., Harris, Edward N.
Publicado no Nucleic Acids Res (2016)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Por Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Publicado no Nucleic Acids Res (2017)

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

Por Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.
Publicado em 2013

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Por Mattis, Virginia B., Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E., Southwell, Amber L., Doty, Crystal N., Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R., Ross, Christopher A., Svendsen, Clive N.
Publicado no Hum Mol Genet (2015)

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

Por Skotte, Niels H., Southwell, Amber L., Østergaard, Michael E., Carroll, Jeffrey B., Warby, Simon C., Doty, Crystal N., Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T., Freier, Susan M., Hung, Gene, Seth, Punit P., Bennett, C. Frank, Swayze, Eric E., Hayden, Michael R.
Publicado em 2014

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides

Por Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R
Publicado no Mol Ther (2014)