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Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA) – A Nuclease Stable Mimic of 2′-Fluoro RNA

We report the design and synthesis of 2′-fluoro cyclohexenyl nucleic acid (F-CeNA) pyrimidine phosphoramidites and the synthesis and biophysical, structural, and biological evaluation of modified oligonucleotides. The synthesis of the nucleoside phosphoramidites was accomplished in multigram quantit...

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Dettagli Bibliografici
Autori principali: Seth, Punit P., Yu, Jinghua, Jazayeri, Ali, Pallan, Pradeep S., Allerson, Charles R, Østergaard, Michael E., Liu, Fengwu, Herdewijn, Piet, Egli, Martin, Swayze, Eric E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696582/
https://ncbi.nlm.nih.gov/pubmed/22591005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo300594b
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