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Insights from Crystal Structures into the Opposite Effects on RNA Affinity by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid (FHNA)()
Locked nucleic acid (LNA) analogs with 2′,4′-bridged sugars show promise in antisense applications. S-5′-Me-LNA has high RNA affinity and modified oligonucleotides show reduced immune stimulation in vivo. Conversely, an R-5′-methyl group dramatically lowers RNA affinity. To test the effects of S- an...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3257178/ https://ncbi.nlm.nih.gov/pubmed/22229409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201810r |
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