Insights from Crystal Structures into the Opposite Effects on RNA Affinity by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid (FHNA)()

Locked nucleic acid (LNA) analogs with 2′,4′-bridged sugars show promise in antisense applications. S-5′-Me-LNA has high RNA affinity and modified oligonucleotides show reduced immune stimulation in vivo. Conversely, an R-5′-methyl group dramatically lowers RNA affinity. To test the effects of S- an...

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Bibliographic Details
Main Authors: Pallan, Pradeep S., Yu, Jinghua, Allerson, Charles R., Swayze, Eric E., Seth, Punit, Egli, Martin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257178/
https://ncbi.nlm.nih.gov/pubmed/22229409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201810r
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