Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

The synthesis, biophysical, structural and biological properties of both isomers of 3′-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides are reported. Synthesis of the FHNA and Ara-FHNA thymine phosphoramidites was efficiently accomplished starting from known sugar precursors...

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Detalhes bibliográficos
Main Authors: Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192227/
https://ncbi.nlm.nih.gov/pubmed/21919455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207086x
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