טוען...
An Exocyclic Methylene Group Acts As A Bio-isostere of the 2’-Oxygen Atom in LNA
We show for the first time that it is possible to obtain LNA (Locked Nucleic Acid 1) like binding affinity and biological activity with carbocyclic LNA (cLNA) analogs by replacing the 2’-oxygen atom in LNA with an exocyclic methylene group. Synthesis of the methylene-cLNA nucleoside was accomplished...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993159/ https://ncbi.nlm.nih.gov/pubmed/20886816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105875e |
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