An Exocyclic Methylene Group Acts As A Bio-isostere of the 2’-Oxygen Atom in LNA

Lignende værker

• Synthesis, Duplex Stabilization and Structural Properties of a Fluorinated Carbocyclic LNA Analog
  af: Seth, Punit P., et al.
  Udgivet: (2012)
• Structure and Nuclease Resistance of 2′,4′-Constrained 2′-O-Methoxyethyl (cMOE) and 2′-O-Ethyl (cEt) Modified DNAs
  af: Pallan, Pradeep S., et al.
  Udgivet: (2012)
• Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides
  af: Egli, Martin, et al.
  Udgivet: (2011)
• Insights from Crystal Structures into the Opposite Effects on RNA Affinity by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid (FHNA)()
  af: Pallan, Pradeep S., et al.
  Udgivet: (2011)
• Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
  af: Seth, Punit P, et al.
  Udgivet: (2012)