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Structure and Nuclease Resistance of 2′,4′-Constrained 2′-O-Methoxyethyl (cMOE) and 2′-O-Ethyl (cEt) Modified DNAs
Combining the structural elements of the second generation 2′-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2′,4′-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal struct...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404228/ https://ncbi.nlm.nih.gov/pubmed/22614180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2cc32286b |
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