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Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA
Various chemical modifications are currently being evaluated for improving the efficacy of short interfering RNA (siRNA) duplexes as antisense agents for gene silencing in vivo. Among the 2′-ribose modifications assessed to date, 2′deoxy-2′-fluoro-RNA (2′-F-RNA) has unique properties for RNA interfe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082899/ https://ncbi.nlm.nih.gov/pubmed/21183463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1270 |
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