Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA

Various chemical modifications are currently being evaluated for improving the efficacy of short interfering RNA (siRNA) duplexes as antisense agents for gene silencing in vivo. Among the 2′-ribose modifications assessed to date, 2′deoxy-2′-fluoro-RNA (2′-F-RNA) has unique properties for RNA interfe...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Pallan, Pradeep S., Greene, Emily M., Jicman, Paul Andrei, Pandey, Rajendra K., Manoharan, Muthiah, Rozners, Eriks, Egli, Martin
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082899/
https://ncbi.nlm.nih.gov/pubmed/21183463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1270
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires