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Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA
DNA and RNA oligonucleotides having formacetal internucleoside linkages between uridine and adenosine nucleosides have been prepared and studied using UV thermal melting, osmotic stress and X-ray crystallography. Formacetal modifications have remarkably different effect on double helical RNA and DNA...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823299/ https://ncbi.nlm.nih.gov/pubmed/19824732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja904926e |
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