Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA

DNA and RNA oligonucleotides having formacetal internucleoside linkages between uridine and adenosine nucleosides have been prepared and studied using UV thermal melting, osmotic stress and X-ray crystallography. Formacetal modifications have remarkably different effect on double helical RNA and DNA...

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Bibliografiske detaljer
Main Authors: Kolarovic, Andrej, Schweizer, Emma, Greene, Emily, Gironda, Mark, Pallan, Pradeep S., Egli, Martin, Rozners, Eriks
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823299/
https://ncbi.nlm.nih.gov/pubmed/19824732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja904926e
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