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A Conformational Transition in the Structure of a 2′-Thiomethyl-Modified DNA Visualized at High Resolution
Crystal structures of A-form and B-form DNA duplexes containing 2′-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3′-endo pucker, illustrating that the replacement of electronegative oxygen at the 2′-carbon of RNA by sulfur does not appear to fundamentally alter the conformati...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909737/ https://ncbi.nlm.nih.gov/pubmed/19333476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b822781k |
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