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Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Antisense oligonucleotides (ASOs) have the potential to discriminate between subtle RNA mismatches such as SNPs. Certain mismatches, however, allow ASOs to bind at physiological conditions and result in RNA cleavage mediated by RNase H. We showed that replacing DNA nucleotides in the gap region of a...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther Nucleic Acids
Asıl Yazarlar: Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Gene & Cell Therapy 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363678/
https://ncbi.nlm.nih.gov/pubmed/28624195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.02.001
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